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The human skull is an especially delicate area for surgery. To differentiate healthy tissue from tumor cells, or treat an aneurysm for example, the surgeon needs a complete picture of the surgical area. Supplementary information provided by Image Guided Surgery (IGS) or neuro navigation systems, endoscope, and in some cases fluorescence, can support the surgeon’s visualization, insight and intra-surgical orientation. This supplementary visual information is often only viewable on a separate screen, but with image injection technology from Leica it can be overlaid in full high definition (HD) directly into the eyepieces of a surgical microscope.